Serenity Aesthetics & Wellness

Serenity Aesthetics & Wellness is a medical spa on the second floor of a building on Post Street, right in Union Square. It opened in San Francisco in 2006 and works along clinical rather than relaxation lines, blending Korean aesthetic techniques with standard medspa technology.

Treatments here center on injectables (Botox and filler), skin resurfacing, skin tightening, skin rejuvenation and microneedling, plus body contouring and hair loss treatments. The clinic is staffed by a team of nurse practitioners and registered nurses who handle injections and procedures rather than estheticians doing spa-style facials, so this is closer to a cosmetic clinic than a traditional day spa.

It's an adults-only, reservation-required spot, which tracks with the medical nature of the services on offer. Hours run roughly 9:30am to 5:30pm Monday through Friday, with a shorter Saturday window from 10am to 2pm, and it's closed Sundays. Pricing sits in the moderate tier for San Francisco, and past clients have pointed to competitive pricing relative to other downtown medspas as one of the draws.

This is a good fit for someone who already knows they want a specific cosmetic procedure, like filler, Botox, or microneedling, and wants a consultation to talk through options rather than a drop-in massage or soaking experience. Anyone curious about results before committing can also try an AI simulator tool on the clinic's site to preview possible injectable outcomes.